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These trials include the MADIT (Multicenter Automatic Defibrillator Implantation Trial), MUSTT (Multicenter Unsustained Tachycardia Trial), MADIT II, SCD-He FT (Sudden Cardiac Death in Heart Failure Trial), and the COMPANION (Comparison of Medical Therapy, Pacing, and Defibrillation in Chronic Heart Failure) trial.

Prompted by the sudden death of a colleague, Mirowski conceived of an automatic, fully implantable defibrillator.

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Early devices were simple “shock boxes,” offering only high-energy shocks when the patient's heart rate exceeded a cut-off point.